Which organ is known to be the most oxygen-dependent in the body?

The brain is the organ that is most oxygen-dependent in the body due to its high metabolic activity and the nature of its energy demands. Unlike many other tissues, the brain’s energy production relies heavily on aerobic metabolism, which requires a constant supply of oxygen. This organ consumes about 20% of the body's total oxygen, even though it constitutes only about 2% of body weight.

The brain is particularly sensitive to oxygen deprivation; even short periods of hypoxia (lack of oxygen) can lead to irreversible damage. This vulnerability is because brain cells, or neurons, have limited capacity to store energy and cannot effectively utilize alternative energy sources like fatty acids. Therefore, a steady supply of oxygen is crucial for maintaining neural function and overall brain health.

While other organs like the heart, kidneys, and liver are also highly dependent on oxygen, the unique energy requirements and susceptibility to damage place the brain at the forefront regarding oxygen dependence.